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Condesa, Roma, Centro Histórico, Coyoacán, and Polanco stand out as Mexico City's hippest neighborhoods. If you're looking to do some barhopping and want to foot it, you can do so in La Condesa. The Zona Rosa has lost ground to Condesa, Roma, and Polanco in the past few years, but it's still packed on Friday and Saturday nights, and everything is within walking distance. Niza, Florencia, Londres, and Hamburgo streets are teeming with bars and discos.
Night is the key word. People generally take in dinner and a show at 9 or 10 pm, head to bars or nightclubs at midnight, then find a spot for a nightcap or tacos somewhere around 3 am. (Cantinas are the exception; people start hitting them in the late afternoon and most close by 11 pm.)
You should have no trouble getting around on your own Always take official hotel taxis, sitio (stationed) taxis, or use the safe taxi apps Yaxi or Uber; it can be expensive to barhop this way, but your safety is worth the cost.
It housed conquistadors during the 16th century; today the Centro is a Spanish cultural center with daily art exhibits, plays, films, and other events, including occasional live indie, electronic, and rock bands on the terrace of the bar-restaurant.
This sloppy gem of a loft is part metro stop, part college-dorm commons, part debating society, and part pulquería. It's run by 1950s national lightweight boxing champion and folk hero Epiphanio "Pifas" Leyva, and serves beer and pulque (a drink made with the fermented sap of one type of agave plant) to a young, intellectual crowd that loves to sing and dance to the excellent jukebox of punk and local guacapunk (Mexican ska) classics. If you want a rowdy afternoon (the bar is usually closed by 11, and always closed on Sunday), this is the place. Note that it's technically in the Doctores neighborhood, but borders Colonia Roma.
Set in the vault of an art deco bank in the heart of Centro, the capital's coolest jazz joint hosts local and international acts. The intimate setting and enthusiastic audiences seem to bring out the best in performers. It's open Wednesday through Saturday, and offers a small menu of international dishes.
