5 Best Hotels in Villa Borghese, Piazza del Popolo, and Flaminio, Rome

Set in a 19th-century neoclassical palace, this cozy boutique hotel was remodeled to feature high-tech, elegant guest rooms while keeping the core structure, including unique windows and tall ceilings, intact. Spacious rooms feature plush blue velvet furniture, oak desks and bookcases, elegant marble bathrooms, and free Illy coffee. The two-Michelin-starred restaurant, Acquolina, serves innovative seafood dishes. The Acquaroof offers drinks and Mediterranean and Roman cuisine on the romantic top-floor terrace, with incredible 360-degree city views.

With a serene location near the Villa Borghese Gardens and a country-manor feel, this family-run art deco retreat attracts an older, well-off international crowd. The downstairs bar—a magnificent piece of cabinetry—is a conversation piece in itself. Upstairs, modern and antique styles combine to create highly polished opulence in guest rooms.

British brand The Hoxton's first foray into Italy is a design lover's dream filled with 1970s-inspired bespoke furniture, art tomes, and plants that transform the large lobby into intimate seating nooks perfect for socializing and coworking. The signature restaurant, Elio, serves delicious Italian cuisine, while Cugino offers pastries in the morning and creative Spritz cocktails with light bites in the evening. Rooms are modestly sized, with plush beds, Roberts stereos, flatscreen TVs, and free tea and coffee. Minibars have only water and milk, but guests can purchase snacks at the front desk. There's also a large event space called the Apartment, which can be rented out.

The 1960s-era facade of this large, seven-story hotel designed by Gio Ponti contrasts with the turn-of-the-20th-century Italian court decor and the extensive botanical garden outside, resulting in a combination of traditional elegance and contemporary pleasure. Windows in every room overlook an ocean of green, surmounted by St. Peter's dome. The hotel has wonderful indoor and outdoor swimming pools, a piano bar with stained glass and carved walnut appointments, a massive spa, and chamber music in the garden.

Set in a quiet residential neighborhood amid 15 acres of lush Mediterranean parkland, the Rome Cavalieri is a true hilltop oasis with magnificent views as well as three outdoor pools, one indoor pool, and a palatial spa. Rooms (ask for one facing the city) are spacious, with private balconies, striped damask, puffy armchairs, and no shortage of luxe amenities, including a pillow menu and luxurious bath products. The rooftop restaurant, La Pergola, is one of the best in the city.