Domus Mariae
On Ortigia's eastern shore, this hotel, in an unusual twist, is owned by Ursuline nuns, who help to make the mood placid and peaceful, but the accommodations are simple rather than monastic. Guest rooms are bright, modern, and decent for pricey Ortigia; some have sea views, while the others have balconies overlooking the street. There's also a slightly more expensive sister hotel, Domus Mariae Benessere, across the street, with a spa, pool, and fitness room that all guests can use.