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Pisa, like many Italian cities, is best explored on foot, and most of what you'll want to see is within walking distance. The views along the Arno River are particularly grand and shouldn't be missed—there's a feeling of spaciousness that isn't found along the Arno in Florence.
As you set out, note that there are various combination-ticket options for sights on the Piazza del Duomo.
According to legend, the cemetery—a walled structure on the western side of the Piazza dei Miracoli—is filled with earth that returning Crusaders brought back from the Holy Land. Contained within are numerous frescoes, notably The Drunkenness of Noah, by Renaissance artist Benozzo Gozzoli (1422–97), and the disturbing Triumph of Death (14th century; artist uncertain), whose subject matter shows what was on people's minds in a century that saw the ravages of the Black Death.
