Mandalay Bay is famous for a few things: the House of Blues, which brings in some epic concerts throughout the year; the Shark Reef Aquarium, which boasts a 1.6-million-gallon saltwater tank and more than 2,000 animals; and an A-list series of restaurants. A pastiche of flavors is the attraction there, including StripSteak and the Mediterranean Orla from internationally acclaimed chef Michael Mina and the more casual Border Grill from Chefs Mary Sue Milliken and Susan Feniger of TV's Two Hot Tamales fame. Technically the complex hosts three separate hotel brands: Mandalay, W Las Vegas, and the Four Seasons Hotel Las Vegas. If you're into views, W's rooftop Rivea, from French culinary lion Alain Ducasse, Skyfall Panoramic Bar & Lounge, and House of Blues Foundation Room on the 64th floor can make you the equal of any bird.
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Also worth noting: minus5° Ice Bar, which is located in the Mandalay Place shopping corridor that connects Mandalay Bay with Luxor; for the price of admission you get to borrow a parka, waltz into a sub-zero drinking establishment, and throw back vodka from a glass made of ice.