3 Best Hotels in Esquilino and Environs, Rome

Situated in an elegant art nouveau palazzo, built in 1876 as a residence for Prince Philip Don Orsini, this charming hotel is furnished with original artwork and British textiles and feels like a private home. The attention to detail is evident at every turn, from the frescoed halls to the breakfast room. Guests enjoy satellite TV, complimentary Wi-Fi, and a free minibar replenished daily.

A cozy hotel just a stone's throw from Termini Station sounds like some sort of a miracle, and yet, the Morgana welcomes guests with classically designed accommodations and friendly smiles. Rooms feature kitschy striped walls, comfy beds, flowing drapes, satellite TVs, and free Wi-Fi. Breakfast is abundant, and there's free access to a fitness center in the Hotel Ariston, a sister hotel that's just across the street. 

Drawing inspiration from the neighborhood's artsy ethos, the first international hotel brand to open in San Lorenzo functions as a members club, with both traditional rooms and apartments. Amenities include wraparound balconies on every floor, a club restaurant that serves international cuisine, a spa, a state-of-the-art gym, a 42-seat screening room, a content-creation studio, and a rooftop terrace with a pool and outpost of Cecconi's with 360-degree panoramic views. Pets are accepted if they're certified as emotional support animals.