3 Best Hotels in Piazza Navona, Campo de' Fiori, and the Jewish Ghetto, Rome

In an old convent on Via Giulia, one of Rome's romantic ivy-covered streets, the D.O.M (Deo Optimo Maximo) is an ultrachic luxury hotel that resembles an aristocratic casa nobile. The interior design is cool and eclectic, with wood beam ceilings that date from the1600s, original Andy Warhol silkscreens, exposed brick walls, and scripture-inscribed marble slabs from the 15th century. The rooms, in warm neutral browns and grays, overlook the street. For real pampering, book the D.O.M Suite, which has a large terrace with views over typical Roman rooftops and bell towers. The real gem here, though, is the opulent but cozy bar and restaurant, VERVE, run by chef Adriano Magnoli and pastry chef Antonella Mascolo, where you can sit next to the fireplace during the winter or the stunning rooftop in the summer and enjoy some of the city's best cocktails.

Situated in a remodeled Renaissance palazzo with one of the prettiest patio-courtyards in Rome, this hotel is a relaxing retreat close to Campo de' Fiori and Trastevere. Rooms have cherrywood accents, recessed lighting, and luminous marble floors. Some overlook the garden of the historic Palazzo Spada, and others offer a distant glimpse of the cupola of St. Peter's Basilica. Some suites have whirlpool tubs and balconies. The rooftop terrace is a great place to contemplate the city's skyline.

A member of Marriott's Autograph Collection, this boutique hotel is a sleek retreat in the center of the action. The design is clean lined and modern, with amenities like smart TVs, minibars stocked with full-size bottles of wine, and smartphones you can use while exploring the city. The Michelin-starred restaurant, Idylio by Apreda, serves creative cuisine by one of Rome's most renowned chefs, Francesco Apreda (formerly of the Hassler), and the Divinity Terrace on the rooftop offers a relaxing spot for an aperitivo (aperitif) surrounded by the church domes and terra-cotta roofs of Rome.