4 Best Hotels in Piazza Navona, Campo de' Fiori, and the Jewish Ghetto, Rome

The granddaddy of Roman hotels and one of the oldest in the world—the doors first opened in 1467—this charming property is adjacent to the Pantheon and right in the middle of the lovely Piazza della Rotonda. Rooms are small but have been completely renovated and feature frescoes dating from the 17th century. Frederick III, Ariosto, Cagliostro, and Pietro Mascagni (celebrating the premier of his opera Cavalleria rusticana) all graced this hotel with their presence. If you would like a room overlooking the Pantheon, book directly through the hotel website.

In an old convent on Via Giulia, one of Rome's romantic ivy-covered streets, the D.O.M (Deo Optimo Maximo) is an ultrachic luxury hotel that resembles an aristocratic casa nobile. The interior design is cool and eclectic, with wood beam ceilings that date from the1600s, original Andy Warhol silkscreens, exposed brick walls, and scripture-inscribed marble slabs from the 15th century. The rooms, in warm neutral browns and grays, overlook the street. For real pampering, book the D.O.M Suite, which has a large terrace with views over typical Roman rooftops and bell towers. The real gem here, though, is the opulent but cozy bar and restaurant, VERVE, run by chef Adriano Magnoli and pastry chef Antonella Mascolo, where you can sit next to the fireplace during the winter or the stunning rooftop in the summer and enjoy some of the city's best cocktails.

With decor elements such as original wood-beamed ceilings, retro tiles, rich fabrics, contemporary art, and furniture that nods to 1930s and '40s Italian design, there's a hipster feel to this hotel inside a 17th-century palazzo around the corner from Piazza Navona. Top-floor rooms have little terraces where you can enjoy your morning cappuccino; other amenities include free Wi-Fi throughout the building, a coffee and tea maker in every room, and a ground-floor caffè and exhibition space that often promotes works by local artists. 

A member of Marriott's Autograph Collection, this boutique hotel is a sleek retreat in the center of the action. The design is clean lined and modern, with amenities like smart TVs, minibars stocked with full-size bottles of wine, and smartphones you can use while exploring the city. The Michelin-starred restaurant, Idylio by Apreda, serves creative cuisine by one of Rome's most renowned chefs, Francesco Apreda (formerly of the Hassler), and the Divinity Terrace on the rooftop offers a relaxing spot for an aperitivo (aperitif) surrounded by the church domes and terra-cotta roofs of Rome.