11 Best Hotels in The Midlands and Upstate, South Carolina

This charming inn within walking distance of local boutiques and restaurants includes a historic mansion in front, with a modern hotel annex behind the courtyard, each offering well-appointed rooms with a mix of antique furnishings. It is also less than 2 miles from the racing and polo action of the stable district. There are a variety of guest rooms to choose from; premium Jacuzzi and premium suite upgrades are a good value.

Greenville's new centerpiece lodge—directly on the Reedy River at the Liberty Bridge—is also the grandest of Richard Kessler's Grand Bohemian chain. A life-size Native American on a rearing horse sculpture, a stone buffalo, and a 10-foot tall geode greet you before even entering the resplendent lobby, with its bespoke glass antler chandeliers, art gallery, restaurants, and wide porches overlooking the river. Rooms are equally dazzling, furnished with stunning art, and on the 5th floor, 15-foot ceilings.

Built into a historic former furniture store building in the heart of downtown Columbia, Trundle stands out for its focus on service and eclectic decor highlighted by paintings and sculpture throughout the communal areas. Rooms feature exposed brick, faux vintage fridges and modern furniture. An annex with an additional five rooms, dubbed the Flutter Wing, opened in 2024, and the hotel also offers four rental houses in nearby neighborhoods. 

Winston Churchill, Franklin D. Roosevelt, and the Astors have slept at this 19th-century inn, where luxurious facilities—including a spa, restaurant, and a lovely outdoor pool—and authentic Southern hospitality come together to make an outstanding getaway. Massive stone fireplaces, rosewood trim, heart-pine floors, and antiques grace the grand lobby. Guest rooms and suites contain upscale furniture with classic lines, like the sleek, dark-stain, four-poster beds dressed with down pillows and comforters. Choose to soak in the extra-deep tub or relax beside your fireplace. The staff goes above and beyond to accommodate guests.

A short walk from the convention center and hot spot restaurants and nightlife, and housing a lively bar of its own, this hotel is modern and customer-focused. It is outfitted with contemporary art and light fixtures, and flooded with natural light in its loft-like public spaces. Rooms have a sleek, minimalist look. The billiards tables in the lobby, modern gym, on-site lounge, and oversized showers emphasize relaxing and recharging.

This Spanish-style redbrick building with a colonnade, built in the 1900s, holds spacious rooms with high ceilings, pine floors, and period furniture. Because of the theater-dining-and-lodging packages, it's a popular overnight stop for opera house-goers. There are two on-site restaurants—the Veranda (upstairs, with views) and JP's, a cozy brick-and-wood bar.

This extremely colorful (think: plaids over pastels) yet tastefully decorated boutique inn expands upon a century-old historic home, whose original parlors and living rooms serve as a bar, library, and communal areas. You don't have to be a University of South Carolina fan to appreciate the funky aesthetic of a headboard adorned with giant chickens. The Trophy Room restaurant serves breakfast and dinner.

This classy outpost is within walking distance of restaurants and nightlife in the Vista neighborhood. The standard wood furnishings in the guest rooms are bumped up a notch in comfort by Cloud Nine bedding, and the hotel's staff provides attentive service.

Sleek and modern, this new build on a family estate offers an escape to a bucolic setting that's still close to the city and includes upscale amenities like a spa, a large pool, and two restaurants, including the superb Patterson Kitchen + Bar, a stand-alone, glass-walled venture that may be the city's best date night destination. The spacious rooms sport a lustrous, neutral-tone aesthetic, and the cozy sitting room features gold chandeliers, two fireplaces, and lots of marble. 

Ask for a room overlooking the pool or the palm-filled atrium at this conveniently located spot on the north end of Main Street. Note that there's also the Hyatt Place Greenville Downtown—a 10-minute walk away and almost as centrally located.

This 11-story downtown hotel built in 1925 combines old-fashioned appeal with Westin's modern upgrades. Intricate moldings adorn the many columns, complemented by ironwork rails, chandeliers, and restored decorative plasterwork. The large guest rooms have down comforters, marble baths, and high ceilings. The on-site restaurant, Spoonbread, is set in an attractive room with high ceilings, a tiled floor, and sky-blue walls.  The lobby restroom is built into the building's original bank vault.