3 Best Hotels in The Midlands and Upstate, South Carolina

Greenville's new centerpiece lodge—directly on the Reedy River at the Liberty Bridge—is also the grandest of Richard Kessler's Grand Bohemian chain. A life-size Native American on a rearing horse sculpture, a stone buffalo, and a 10-foot tall geode greet you before even entering the resplendent lobby, with its bespoke glass antler chandeliers, art gallery, restaurants, and wide porches overlooking the river. Rooms are equally dazzling, furnished with stunning art, and on the 5th floor, 15-foot ceilings.

Sleek and modern, this new build on a family estate offers an escape to a bucolic setting that's still close to the city and includes upscale amenities like a spa, a large pool, and two restaurants, including the superb Patterson Kitchen + Bar, a stand-alone, glass-walled venture that may be the city's best date night destination. The spacious rooms sport a lustrous, neutral-tone aesthetic, and the cozy sitting room features gold chandeliers, two fireplaces, and lots of marble. 

This 11-story downtown hotel built in 1925 combines old-fashioned appeal with Westin's modern upgrades. Intricate moldings adorn the many columns, complemented by ironwork rails, chandeliers, and restored decorative plasterwork. The large guest rooms have down comforters, marble baths, and high ceilings. The on-site restaurant, Spoonbread, is set in an attractive room with high ceilings, a tiled floor, and sky-blue walls.  The lobby restroom is built into the building's original bank vault.