7 Best Restaurants in Esquilino and Environs, Rome

In this circa-1804 farmhouse you can dine beside the fireplace in cool weather or in the garden under age-old vines in summer. Specialties include risotto with robiola cheese, beets, and hazelnuts, rack of lamb with Jerusalem artichoke, and fresh seafood. The atmosphere is friendly and intimate, but the vast property can also accommodate large parties.

Part of the wave of new restaurants with chefs embracing Rome's traditional cucina povera and making it hip for a younger audience, Mazzo doesn't shy away from off-cuts like tripe. Vintage furniture and vinyl records set the tone, while the wine list focuses on natural and organic wines. For diners who'd rather skip innards, there are plenty of vegetable-focused items and more innocuous pastas on the menu.

Not to be confused with the art foundation also located inside the former Cerere pasta factory, this industrial-chic restaurant wouldn't be out of place in New York or London. Some dishes combine Italian and international flavors with out-of-the-box results, while others feature subtle touches like adding salted ricotta to the fusilloni pasta with smoked tomato sauce. On some evenings, there's live music or a DJ.

Originally opened as a wine shop, this bistro has floor-to-ceiling shelves stacked with some 2,000 bottles from renowned wineries like Antinori and Frescobaldi. Ask for a recommendation to accompany dishes that range from tried-and-true favorites, including tagliatelle al ragù and eggplant parmigiana to a burger or black cod. Save room for the molten chocolate cake or tiramisù served in a moka pot.

Though she hails from Abruzzo, the young chef-owner Sarah Cicolini earned her place as one of the rising stars in Rome's restaurant scene at this trendy trattoria, where she embraces quinto quarto—or the fifth quarter of an animal, like tripe, tail, and heart. Be sure to book ahead for the vintage vibes and superlative carbonara.

There is just a handful of wooden tables crowded into the upstairs and downstairs dining rooms at this family-run trattoria, where the walls are festooned with photographs and soccer jerseys. Owner Danilo Valenti presides over the dining room, while his mother, Pina, whips up Roman classics, including an excellent carbonara, carciofi alla romana, and cacio e pepe that gets tossed tableside in a wheel of pecorino cheese.